RAD50-interacting protein 1 (RINT1)
Homo sapiens — UniProt Q6NUQ1
Data last refreshed: (UniProt release unknown)
Key facts
RAD50-interacting protein 1 (RINT1) is a protein from Homo sapiens identified by UniProt accession Q6NUQ1, 792 residues long. MolForge cross-references it against 0 known binders and 149 disease associations.
- UniProt accession: Q6NUQ1; gene symbol RINT1.
- Organism: Homo sapiens.
- Length: 792 amino acids.
- Top disease associations (Open Targets): Acute infantile liver failure-multisystemic involvement syndrome, Fulminant hepatic failure and thyroid cancer, nonmedullary, 1.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | RAD50-interacting protein 1 |
|---|---|
| UniProt accession | Q6NUQ1 |
| Gene | RINT1 |
| Organism | Homo sapiens |
| Length | 792 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (149)
Diseases linked to this target (Open Targets).
- Acute infantile liver failure-multisystemic involvement syndrome · score 0.68
- Fulminant hepatic failure · score 0.42
- thyroid cancer, nonmedullary, 1 · score 0.40
- familial papillary or follicular thyroid carcinoma · score 0.40
- papillary thyroid carcinoma · score 0.40
- liver failure · score 0.37
- Short stature · score 0.37
- Abnormality of the skeletal system · score 0.37
- infantile liver failure · score 0.37
- Hereditary breast and ovarian cancer syndrome · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6NUQ1-F1 | alphafold | PREDICTED | 85.15 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NUQ1.
Amino-acid sequence (792 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RINT1?
The strongest Open Targets associations for RINT1 are Acute infantile liver failure-multisystemic involvement syndrome, Fulminant hepatic failure, thyroid cancer, nonmedullary, 1, familial papillary or follicular thyroid carcinoma and papillary thyroid carcinoma.
How long is the RINT1 protein?
The Homo sapiens RINT1 protein (UniProt Q6NUQ1) is 792 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6NUQ1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6NUQ1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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