Transmembrane protein 214 (TMEM214)
Homo sapiens — UniProt Q6NUQ4
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 214 (TMEM214) is a protein from Homo sapiens identified by UniProt accession Q6NUQ4, 689 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.
- UniProt accession: Q6NUQ4; gene symbol TMEM214.
- Organism: Homo sapiens.
- Length: 689 amino acids.
- Top disease associations (Open Targets): neutrophil count, myeloid white cell count and neutrophil percentage of leukocytes.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 214 |
|---|---|
| UniProt accession | Q6NUQ4 |
| Gene | TMEM214 |
| Organism | Homo sapiens |
| Length | 689 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (26)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.25
- myeloid white cell count · score 0.16
- neutrophil percentage of leukocytes · score 0.14
- leukocyte count · score 0.13
- lymphocyte percentage of leukocytes · score 0.11
- autism · score 0.11
- Flexion contracture · score 0.11
- risk-taking behaviour · score 0.05
- cortical surface area measurement · score 0.05
- cortical thickness · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6NUQ4-F1 | alphafold | PREDICTED | 78.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NUQ4.
Amino-acid sequence (689 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM214?
The strongest Open Targets associations for TMEM214 are neutrophil count, myeloid white cell count, neutrophil percentage of leukocytes, leukocyte count and lymphocyte percentage of leukocytes.
How long is the TMEM214 protein?
The Homo sapiens TMEM214 protein (UniProt Q6NUQ4) is 689 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6NUQ4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6NUQ4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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