About UDP-glucuronosyltransferase 3A1
UDP-glucuronosyltransferase 3A1 (UGT3A1) is a protein
from Homo sapiens identified by UniProt accession
Q6NUS8, 523 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | UDP-glucuronosyltransferase 3A1 |
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| UniProt accession | Q6NUS8 |
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| Gene | UGT3A1 |
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| Organism | Homo sapiens |
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| Length | 523 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (38)
Diseases linked to this target (Open Targets).
- serum metabolite measurement · score 0.47
- urinary metabolite measurement · score 0.41
- estradiol measurement · score 0.39
- blood metabolite measurement · score 0.33
- serum non-albumin protein measurement · score 0.25
- eosinophil percentage of leukocytes · score 0.23
- asthma · score 0.19
- cutaneous melanoma · score 0.18
- lung adenocarcinoma · score 0.17
- glioblastoma multiforme · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6NUS8-F1 | alphafold | PREDICTED | 91.42 | — |
Amino-acid sequence (523 residues)
MVGQRVLLLV AFLLSGVLLS EAAKILTIST LGGSHYLLLD RVSQILQEHG HNVTMLHQSG KFLIPDIKEE EKSYQVIRWF SPEDHQKRIK KHFDSYIETA LDGRKESEAL VKLMEIFGTQ CSYLLSRKDI MDSLKNENYD LVFVEAFDFC SFLIAEKLVK PFVAILPTTF GSLDFGLPSP LSYVPVFPSL LTDHMDFWGR VKNFLMFFSF SRSQWDMQST FDNTIKEHFP EGSRPVLSHL LLKAELWFVN SDFAFDFARP LLPNTVYIGG LMEKPIKPVP QDLDNFIANF GDAGFVLVAF GSMLNTHQSQ EVLKKMHNAF AHLPQGVIWT CQSSHWPRDV HLATNVKIVD WLPQSDLLAH PSIRLFVTHG GQNSVMEAIR HGVPMVGLPV NGDQHGNMVR VVAKNYGVSI RLNQVTADTL TLTMKQVIED KRYKSAVVAA SVILHSQPLS PAQRLVGWID HILQTGGATH LKPYAFQQPW HEQYLIDVFV FLLGLTLGTM WLCGKLLGVV ARWLRGARKV KKT
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