Probable G-protein coupled receptor 153 (GPR153)
Homo sapiens — UniProt Q6NV75
Data last refreshed: (UniProt release unknown)
Key facts
Probable G-protein coupled receptor 153 (GPR153) is a protein from Homo sapiens identified by UniProt accession Q6NV75, 609 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.
- UniProt accession: Q6NV75; gene symbol GPR153.
- Organism: Homo sapiens.
- Length: 609 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Rare pervasive developmental disorder and QT interval.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable G-protein coupled receptor 153 |
|---|---|
| UniProt accession | Q6NV75 |
| Gene | GPR153 |
| Organism | Homo sapiens |
| Length | 609 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (23)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.29
- Rare pervasive developmental disorder · score 0.27
- QT interval · score 0.13
- electrocardiography · score 0.08
- attention deficit hyperactivity disorder · score 0.07
- Tourette syndrome · score 0.05
- attention deficit-hyperactivity disorder 8 · score 0.05
- Mobius syndrome · score 0.05
- Potocki-Lupski syndrome · score 0.05
- schizophrenia 15 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6NV75-F1 | alphafold | PREDICTED | 65.15 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NV75.
Amino-acid sequence (609 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GPR153?
The strongest Open Targets associations for GPR153 are neurodegenerative disease, Rare pervasive developmental disorder, QT interval, electrocardiography and attention deficit hyperactivity disorder.
How long is the GPR153 protein?
The Homo sapiens GPR153 protein (UniProt Q6NV75) is 609 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6NV75 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6NV75 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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