Magnesium transporter NIPA3 (NIPAL1)
Homo sapiens — UniProt Q6NVV3
Data last refreshed: (UniProt release unknown)
Key facts
Magnesium transporter NIPA3 (NIPAL1) is a protein from Homo sapiens identified by UniProt accession Q6NVV3, 410 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.
- UniProt accession: Q6NVV3; gene symbol NIPAL1.
- Organism: Homo sapiens.
- Length: 410 amino acids.
- Target class: Transporter.
- Top disease associations (Open Targets): aspartate aminotransferase measurement, mean platelet volume and serum metabolite measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Magnesium transporter NIPA3 |
|---|---|
| UniProt accession | Q6NVV3 |
| Gene | NIPAL1 |
| Organism | Homo sapiens |
| Length | 410 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (29)
Diseases linked to this target (Open Targets).
- aspartate aminotransferase measurement · score 0.39
- mean platelet volume · score 0.33
- serum metabolite measurement · score 0.28
- urate measurement · score 0.21
- gout · score 0.19
- uterine fibroid · score 0.07
- Uterine leiomyoma · score 0.06
- Gout · score 0.05
- breast carcinoma · score 0.04
- oral squamous cell carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6NVV3-F1 | alphafold | PREDICTED | 81.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NVV3.
Amino-acid sequence (410 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NIPAL1?
The strongest Open Targets associations for NIPAL1 are aspartate aminotransferase measurement, mean platelet volume, serum metabolite measurement, urate measurement and gout.
How long is the NIPAL1 protein?
The Homo sapiens NIPAL1 protein (UniProt Q6NVV3) is 410 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6NVV3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6NVV3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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