3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (HIBCH)
Homo sapiens — UniProt Q6NVY1
Data last refreshed: (UniProt release unknown)
Key facts
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (HIBCH) is a protein from Homo sapiens identified by UniProt accession Q6NVY1, 386 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.
- UniProt accession: Q6NVY1; gene symbol HIBCH.
- Organism: Homo sapiens.
- Length: 386 amino acids.
- Top disease associations (Open Targets): Neurodegeneration due to 3-hydroxyisobutyryl-CoA hydrolase deficiency, 3-hydroxyisobutyryl-CoA hydrolase deficiency and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial |
|---|---|
| UniProt accession | Q6NVY1 |
| Gene | HIBCH |
| Organism | Homo sapiens |
| Length | 386 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (83)
Diseases linked to this target (Open Targets).
- Neurodegeneration due to 3-hydroxyisobutyryl-CoA hydrolase deficiency · score 0.78
- 3-hydroxyisobutyryl-CoA hydrolase deficiency · score 0.74
- genetic disorder · score 0.46
- neurodegenerative disease · score 0.46
- protein measurement · score 0.43
- Leigh syndrome · score 0.37
- blood protein measurement · score 0.36
- reticulocyte count · score 0.34
- urinary metabolite measurement · score 0.34
- reticulocyte measurement · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6NVY1-F1 | alphafold | PREDICTED | 93.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NVY1.
Amino-acid sequence (386 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HIBCH?
The strongest Open Targets associations for HIBCH are Neurodegeneration due to 3-hydroxyisobutyryl-CoA hydrolase deficiency, 3-hydroxyisobutyryl-CoA hydrolase deficiency, genetic disorder, neurodegenerative disease and protein measurement.
How long is the HIBCH protein?
The Homo sapiens HIBCH protein (UniProt Q6NVY1) is 386 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6NVY1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6NVY1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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