Repulsive guidance molecule B (RGMB)
Homo sapiens — UniProt Q6NW40
Data last refreshed: (UniProt release unknown)
Key facts
Repulsive guidance molecule B (RGMB) is a protein from Homo sapiens identified by UniProt accession Q6NW40, 437 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.
- UniProt accession: Q6NW40; gene symbol RGMB.
- Organism: Homo sapiens.
- Length: 437 amino acids.
- Top disease associations (Open Targets): reticulocyte count, hair colour measurement and forced expiratory volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Repulsive guidance molecule B |
|---|---|
| UniProt accession | Q6NW40 |
| Gene | RGMB |
| Organism | Homo sapiens |
| Length | 437 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (88)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.36
- hair colour measurement · score 0.33
- forced expiratory volume · score 0.32
- Parkinson disease · score 0.31
- Alzheimer disease · score 0.31
- neurodegenerative disease · score 0.31
- lysosomal storage disease · score 0.31
- multiple sclerosis · score 0.31
- basophil count · score 0.29
- systolic blood pressure · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6NW40-F1 | alphafold | PREDICTED | 79.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NW40.
Amino-acid sequence (437 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RGMB?
The strongest Open Targets associations for RGMB are reticulocyte count, hair colour measurement, forced expiratory volume, Parkinson disease and Alzheimer disease.
How long is the RGMB protein?
The Homo sapiens RGMB protein (UniProt Q6NW40) is 437 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6NW40 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6NW40 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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