Pre-mRNA-processing factor 40 homolog B (PRPF40B)
Homo sapiens — UniProt Q6NWY9
Data last refreshed: (UniProt release unknown)
Key facts
Pre-mRNA-processing factor 40 homolog B (PRPF40B) is a protein from Homo sapiens identified by UniProt accession Q6NWY9, 871 residues long. MolForge cross-references it against 0 known binders and 118 disease associations.
- UniProt accession: Q6NWY9; gene symbol PRPF40B.
- Organism: Homo sapiens.
- Length: 871 amino acids.
- Top disease associations (Open Targets): nephronophthisis, pulse pressure measurement and acute myeloid leukemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pre-mRNA-processing factor 40 homolog B |
|---|---|
| UniProt accession | Q6NWY9 |
| Gene | PRPF40B |
| Organism | Homo sapiens |
| Length | 871 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (118)
Diseases linked to this target (Open Targets).
- nephronophthisis · score 0.26
- pulse pressure measurement · score 0.20
- acute myeloid leukemia · score 0.19
- cervical squamous cell carcinoma · score 0.19
- myelodysplastic syndrome · score 0.19
- hepatocellular carcinoma · score 0.18
- breast carcinoma · score 0.18
- acute lymphoblastic leukemia · score 0.18
- head and neck squamous cell carcinoma · score 0.18
- T-cell acute lymphoblastic leukemia · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6NWY9-F1 | alphafold | PREDICTED | 67.75 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NWY9.
Amino-acid sequence (871 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PRPF40B?
The strongest Open Targets associations for PRPF40B are nephronophthisis, pulse pressure measurement, acute myeloid leukemia, cervical squamous cell carcinoma and myelodysplastic syndrome.
How long is the PRPF40B protein?
The Homo sapiens PRPF40B protein (UniProt Q6NWY9) is 871 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6NWY9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6NWY9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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