Epithelial splicing regulatory protein 1 (ESRP1)
Homo sapiens — UniProt Q6NXG1
Data last refreshed: (UniProt release unknown)
Key facts
Epithelial splicing regulatory protein 1 (ESRP1) is a protein from Homo sapiens identified by UniProt accession Q6NXG1, 681 residues long. MolForge cross-references it against 0 known binders and 261 disease associations.
- UniProt accession: Q6NXG1; gene symbol ESRP1.
- Organism: Homo sapiens.
- Length: 681 amino acids.
- Top disease associations (Open Targets): cancer, neurodegenerative disease and hearing loss, autosomal recessive.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Epithelial splicing regulatory protein 1 |
|---|---|
| UniProt accession | Q6NXG1 |
| Gene | ESRP1 |
| Organism | Homo sapiens |
| Length | 681 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (261)
Diseases linked to this target (Open Targets).
- cancer · score 0.57
- neurodegenerative disease · score 0.52
- hearing loss, autosomal recessive · score 0.43
- urate measurement · score 0.28
- self reported educational attainment · score 0.28
- thyroid gland adenocarcinoma · score 0.28
- lung adenocarcinoma · score 0.27
- body mass index · score 0.26
- glioblastoma multiforme · score 0.23
- diet measurement · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6NXG1-F1 | alphafold | PREDICTED | 77.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NXG1.
Amino-acid sequence (681 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ESRP1?
The strongest Open Targets associations for ESRP1 are cancer, neurodegenerative disease, hearing loss, autosomal recessive, urate measurement and self reported educational attainment.
How long is the ESRP1 protein?
The Homo sapiens ESRP1 protein (UniProt Q6NXG1) is 681 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6NXG1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6NXG1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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