EF-hand calcium-binding domain-containing protein 12 (EFCAB12)
Homo sapiens — UniProt Q6NXP0
Data last refreshed: (UniProt release unknown)
Key facts
EF-hand calcium-binding domain-containing protein 12 (EFCAB12) is a protein from Homo sapiens identified by UniProt accession Q6NXP0, 572 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.
- UniProt accession: Q6NXP0; gene symbol EFCAB12.
- Organism: Homo sapiens.
- Length: 572 amino acids.
- Top disease associations (Open Targets): BMI-adjusted waist-hip ratio, low density lipoprotein cholesterol measurement and systemic lupus erythematosus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | EF-hand calcium-binding domain-containing protein 12 |
|---|---|
| UniProt accession | Q6NXP0 |
| Gene | EFCAB12 |
| Organism | Homo sapiens |
| Length | 572 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (14)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist-hip ratio · score 0.33
- low density lipoprotein cholesterol measurement · score 0.18
- systemic lupus erythematosus · score 0.16
- serum gamma-glutamyl transferase measurement · score 0.15
- autism · score 0.11
- cortical thickness · score 0.03
- lymphocyte count · score 0.02
- leukocyte count · score 0.02
- ependymoma · score 0.01
- COVID-19 · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6NXP0-F1 | alphafold | PREDICTED | 65.13 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NXP0.
Amino-acid sequence (572 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EFCAB12?
The strongest Open Targets associations for EFCAB12 are BMI-adjusted waist-hip ratio, low density lipoprotein cholesterol measurement, systemic lupus erythematosus, serum gamma-glutamyl transferase measurement and autism.
How long is the EFCAB12 protein?
The Homo sapiens EFCAB12 protein (UniProt Q6NXP0) is 572 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6NXP0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6NXP0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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