Golgi-associated RAB2 interactor protein 1A (GARIN1A)
Homo sapiens — UniProt Q6NXP2
Data last refreshed: (UniProt release unknown)
Key facts
Golgi-associated RAB2 interactor protein 1A (GARIN1A) is a protein from Homo sapiens identified by UniProt accession Q6NXP2, 309 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.
- UniProt accession: Q6NXP2; gene symbol GARIN1A.
- Organism: Homo sapiens.
- Length: 309 amino acids.
- Top disease associations (Open Targets): azoospermia, male infertility with teratozoospermia due to single gene mutation and partial chromosome Y deletion.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Golgi-associated RAB2 interactor protein 1A |
|---|---|
| UniProt accession | Q6NXP2 |
| Gene | GARIN1A |
| Organism | Homo sapiens |
| Length | 309 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (78)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- partial chromosome Y deletion · score 0.07
- spermatogenic failure 20 · score 0.07
- spermatogenic failure 72 · score 0.06
- spermatogenic failure 27 · score 0.06
- spermatogenic failure 18 · score 0.06
- spermatogenic failure 46 · score 0.06
- spermatogenic failure 42 · score 0.06
- spermatogenic failure 5 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6NXP2-F1 | alphafold | PREDICTED | 63.69 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NXP2.
Amino-acid sequence (309 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GARIN1A?
The strongest Open Targets associations for GARIN1A are azoospermia, male infertility with teratozoospermia due to single gene mutation, partial chromosome Y deletion, spermatogenic failure 20 and spermatogenic failure 72.
How long is the GARIN1A protein?
The Homo sapiens GARIN1A protein (UniProt Q6NXP2) is 309 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6NXP2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6NXP2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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