Interferon-inducible GTPase 5 (IRGC)
Homo sapiens — UniProt Q6NXR0
Data last refreshed: (UniProt release unknown)
Key facts
Interferon-inducible GTPase 5 (IRGC) is a protein from Homo sapiens identified by UniProt accession Q6NXR0, 463 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.
- UniProt accession: Q6NXR0; gene symbol IRGC.
- Organism: Homo sapiens.
- Length: 463 amino acids.
- Top disease associations (Open Targets): genetic disorder, azoospermia and male infertility with teratozoospermia due to single gene mutation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Interferon-inducible GTPase 5 |
|---|---|
| UniProt accession | Q6NXR0 |
| Gene | IRGC |
| Organism | Homo sapiens |
| Length | 463 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (76)
Diseases linked to this target (Open Targets).
- genetic disorder · score 0.12
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- spermatogenic failure 72 · score 0.06
- spermatogenic failure 46 · score 0.06
- spermatogenic failure 18 · score 0.06
- spermatogenic failure 27 · score 0.06
- spermatogenic failure 65 · score 0.06
- spermatogenic failure 49 · score 0.06
- spermatogenic failure 43 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6NXR0-F1 | alphafold | PREDICTED | 68.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NXR0.
Amino-acid sequence (463 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IRGC?
The strongest Open Targets associations for IRGC are genetic disorder, azoospermia, male infertility with teratozoospermia due to single gene mutation, spermatogenic failure 72 and spermatogenic failure 46.
How long is the IRGC protein?
The Homo sapiens IRGC protein (UniProt Q6NXR0) is 463 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6NXR0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6NXR0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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