About TELO2-interacting protein 2
TELO2-interacting protein 2 (TTI2) is a protein
from Homo sapiens identified by UniProt accession
Q6NXR4, 508 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
Disease associations (41)
Diseases linked to this target (Open Targets).
- severe intellectual disability-short stature-behavioral abnormalities-facial dysmorphism syndrome · score 0.65
- Severe intellectual disability-short stature-behavioral troubles-facial dysmorphism syndrome · score 0.55
- neurodegenerative disease · score 0.53
- autosomal recessive non-syndromic intellectual disability · score 0.48
- lysosomal storage disease · score 0.35
- genetic disorder · score 0.19
- pulse pressure measurement · score 0.15
- blood protein measurement · score 0.15
- Microcephaly · score 0.14
- chronotype measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q6NXR4.
Amino-acid sequence (508 residues)
MELDSALEAP SQEDSNLSEE LSHSAFGQAF SKILHCLARP EARRGNVKDA VLKDLGDLIE ATEFDRLFEG TGARLRGMPE TLGQVAKALE KYAAPSKEEE GGGDGHSEAA EKAAQVGLLF LKLLGKVETA KNSLVGPAWQ TGLHHLAGPV YIFAITHSLE QPWTTPRSRE VAREVLTSLL QVTECGSVAG FLHGENEDEK GRLSVILGLL KPDLYKESWK NNPAIKHVFS WTLQQVTRPW LSQHLERVLP ASLVISDDYQ TENKILGVHC LHHIVLNVPA ADLLQYNRAQ VLYHAISNHL YTPEHHLIQA VLLCLLDLFP ILEKTLHWKG DGARPTTHCD EVLRLILTHM EPEHRLLLRR TYARNLPAFV NRLGILTVRH LKRLERVIIG YLEVYDGPEE EARLKILETL KLLMQHTWPR VSCRLVVLLK ALLKLICDVA RDPNLTPESV KSALLQEATD CLILLDRCSQ GRVKGLLAKI PQSCEDRKVV NYIRKVQQVS EGAPYNGT
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