Ankyrin repeat domain-containing protein 54 (ANKRD54)
Homo sapiens — UniProt Q6NXT1
Data last refreshed: (UniProt release unknown)
Key facts
Ankyrin repeat domain-containing protein 54 (ANKRD54) is a protein from Homo sapiens identified by UniProt accession Q6NXT1, 300 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.
- UniProt accession: Q6NXT1; gene symbol ANKRD54.
- Organism: Homo sapiens.
- Length: 300 amino acids.
- Top disease associations (Open Targets): alkaline phosphatase measurement, heel bone mineral density and bone quantitative ultrasound measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ankyrin repeat domain-containing protein 54 |
|---|---|
| UniProt accession | Q6NXT1 |
| Gene | ANKRD54 |
| Organism | Homo sapiens |
| Length | 300 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (21)
Diseases linked to this target (Open Targets).
- alkaline phosphatase measurement · score 0.11
- heel bone mineral density · score 0.06
- bone quantitative ultrasound measurement · score 0.03
- white matter microstructure measurement · score 0.03
- refractive error measurement · score 0.03
- sensorineural hearing loss · score 0.03
- erythrocyte count · score 0.02
- disorder of ear · score 0.02
- age-related hearing impairment · score 0.02
- diet measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6NXT1-F1 | alphafold | PREDICTED | 68.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NXT1.
Amino-acid sequence (300 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ANKRD54?
The strongest Open Targets associations for ANKRD54 are alkaline phosphatase measurement, heel bone mineral density, bone quantitative ultrasound measurement, white matter microstructure measurement and refractive error measurement.
How long is the ANKRD54 protein?
The Homo sapiens ANKRD54 protein (UniProt Q6NXT1) is 300 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6NXT1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6NXT1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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