Zinc transporter 6 (SLC30A6)

About Zinc transporter 6

Zinc transporter 6 (SLC30A6) is a protein from Homo sapiens identified by UniProt accession Q6NXT4, 461 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.

Target properties

Protein name	Zinc transporter 6
UniProt accession	Q6NXT4
Gene	SLC30A6
Organism	Homo sapiens
Length	461 residues
Molecular weight	—
EC numbers	—
Target class	Transporter (inferred from UniProt keywords / EC)
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (65)

Diseases linked to this target (Open Targets).

Autosomal dominant spastic paraplegia type 4 · score 0.53
hereditary spastic paraplegia 4 · score 0.53
interleukin 18 measurement · score 0.12
acute myeloid leukemia · score 0.11
glucuronate measurement · score 0.09
blood protein measurement · score 0.08
Fuchs endothelial corneal dystrophy · score 0.07
Lisch epithelial corneal dystrophy · score 0.07
lymphocyte count · score 0.06
keratoconus 1 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6NXT4-F1	alphafold	PREDICTED	71.04	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NXT4.

Amino-acid sequence (461 residues)

MGTIHLFRKP QRSFFGKLLR EFRLVAADRR SWKILLFGVI NLICTGFLLM WCSSTNSIAL TAYTYLTIFD LFSLMTCLIS YWVTLRKPSP VYSFGFERLE VLAVFASTVL AQLGALFILK ESAERFLEQP EIHTGRLLVG TFVALCFNLF TMLSIRNKPF AYVSEAASTS WLQEHVADLS RSLCGIIPGL SSIFLPRMNP FVLIDLAGAF ALCITYMLIE INNYFAVDTA SAIAIALMTF GTMYPMSVYS GKVLLQTTPP HVIGQLDKLI REVSTLDGVL EVRNEHFWTL GFGSLAGSVH VRIRRDANEQ MVLAHVTNRL YTLVSTLTVQ IFKDDWIRPA LLSGPVAANV LNFSDHHVIP MPLLKGTDDL NPVTSTPAKP SSPPPEFSFN TPGKNVNPVI LLNTQTRPYG FGLNHGHTPY SSMLNQGLGV PGIGATQGLR TGFTNIPSRY GTNNRIGQPR P

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards