KN motif and ankyrin repeat domain-containing protein 3 (KANK3)
Homo sapiens — UniProt Q6NY19
Data last refreshed: (UniProt release unknown)
Key facts
KN motif and ankyrin repeat domain-containing protein 3 (KANK3) is a protein from Homo sapiens identified by UniProt accession Q6NY19, 821 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q6NY19; gene symbol KANK3.
- Organism: Homo sapiens.
- Length: 821 amino acids.
- Top disease associations (Open Targets): diastolic blood pressure, blood coagulation disease and reticulocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | KN motif and ankyrin repeat domain-containing protein 3 |
|---|---|
| UniProt accession | Q6NY19 |
| Gene | KANK3 |
| Organism | Homo sapiens |
| Length | 821 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- diastolic blood pressure · score 0.31
- blood coagulation disease · score 0.30
- reticulocyte count · score 0.18
- Red cell distribution width · score 0.05
- mean platelet volume · score 0.04
- lung adenocarcinoma · score 0.04
- high density lipoprotein cholesterol measurement · score 0.03
- apolipoprotein A 1 measurement · score 0.03
- triglyceride measurement · score 0.03
- non-small cell lung carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6NY19-F1 | alphafold | PREDICTED | 64.16 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NY19.
Amino-acid sequence (821 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KANK3?
The strongest Open Targets associations for KANK3 are diastolic blood pressure, blood coagulation disease, reticulocyte count, Red cell distribution width and mean platelet volume.
How long is the KANK3 protein?
The Homo sapiens KANK3 protein (UniProt Q6NY19) is 821 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6NY19 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6NY19 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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