Phostensin (PPP1R18)
Homo sapiens — UniProt Q6NYC8
Data last refreshed: (UniProt release unknown)
Key facts
Phostensin (PPP1R18) is a protein from Homo sapiens identified by UniProt accession Q6NYC8, 613 residues long. MolForge cross-references it against 0 known binders and 163 disease associations.
- UniProt accession: Q6NYC8; gene symbol PPP1R18.
- Organism: Homo sapiens.
- Length: 613 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, inflammatory bowel disease and cutaneous lupus erythematosus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phostensin |
|---|---|
| UniProt accession | Q6NYC8 |
| Gene | PPP1R18 |
| Organism | Homo sapiens |
| Length | 613 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (163)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- inflammatory bowel disease · score 0.14
- cutaneous lupus erythematosus · score 0.10
- BMI-adjusted waist-hip ratio · score 0.10
- reticular dysgenesis · score 0.07
- upper aerodigestive tract neoplasm · score 0.07
- common variable immunodeficiency · score 0.06
- neutrophil immunodeficiency syndrome · score 0.06
- combined immunodeficiency with skin granulomas · score 0.06
- severe combined immunodeficiency due to CTPS1 deficiency · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6NYC8-F1 | alphafold | PREDICTED | 53.51 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NYC8.
Amino-acid sequence (613 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PPP1R18?
The strongest Open Targets associations for PPP1R18 are neurodegenerative disease, inflammatory bowel disease, cutaneous lupus erythematosus, BMI-adjusted waist-hip ratio and reticular dysgenesis.
How long is the PPP1R18 protein?
The Homo sapiens PPP1R18 protein (UniProt Q6NYC8) is 613 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6NYC8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6NYC8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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