Zinc finger CCHC domain-containing protein 8 (ZCCHC8)
Homo sapiens — UniProt Q6NZY4
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger CCHC domain-containing protein 8 (ZCCHC8) is a protein from Homo sapiens identified by UniProt accession Q6NZY4, 707 residues long. MolForge cross-references it against 0 known binders and 160 disease associations.
- UniProt accession: Q6NZY4; gene symbol ZCCHC8.
- Organism: Homo sapiens.
- Length: 707 amino acids.
- Top disease associations (Open Targets): pulmonary fibrosis, and/or bone marrow failure, telomere-related, 5, neurodegenerative disease and dyskeratosis congenita.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger CCHC domain-containing protein 8 |
|---|---|
| UniProt accession | Q6NZY4 |
| Gene | ZCCHC8 |
| Organism | Homo sapiens |
| Length | 707 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (160)
Diseases linked to this target (Open Targets).
- pulmonary fibrosis, and/or bone marrow failure, telomere-related, 5 · score 0.52
- neurodegenerative disease · score 0.46
- dyskeratosis congenita · score 0.35
- inherited aplastic anemia · score 0.33
- inherited acute myeloid leukemia · score 0.27
- body mass index · score 0.24
- body fat percentage · score 0.22
- high density lipoprotein cholesterol measurement · score 0.21
- Red cell distribution width · score 0.21
- bladder transitional cell carcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6NZY4-F1 | alphafold | PREDICTED | 61.22 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NZY4.
Amino-acid sequence (707 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZCCHC8?
The strongest Open Targets associations for ZCCHC8 are pulmonary fibrosis, and/or bone marrow failure, telomere-related, 5, neurodegenerative disease, dyskeratosis congenita, inherited aplastic anemia and inherited acute myeloid leukemia.
How long is the ZCCHC8 protein?
The Homo sapiens ZCCHC8 protein (UniProt Q6NZY4) is 707 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6NZY4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6NZY4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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