Phospholipase B1, membrane-associated (PLB1)
Homo sapiens — UniProt Q6P1J6
Data last refreshed: (UniProt release unknown)
Key facts
Phospholipase B1, membrane-associated (PLB1) is a protein from Homo sapiens identified by UniProt accession Q6P1J6, 1458 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.
- UniProt accession: Q6P1J6; gene symbol PLB1.
- Organism: Homo sapiens.
- Length: 1458 amino acids.
- Top disease associations (Open Targets): eosinophil count, eosinophil percentage of leukocytes and bone density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phospholipase B1, membrane-associated |
|---|---|
| UniProt accession | Q6P1J6 |
| Gene | PLB1 |
| Organism | Homo sapiens |
| Length | 1458 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (106)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.46
- eosinophil percentage of leukocytes · score 0.41
- bone density · score 0.38
- urate measurement · score 0.38
- triglyceride measurement · score 0.34
- heel bone mineral density · score 0.32
- eosinophil percentage of granulocytes · score 0.30
- neutrophil percentage of granulocytes · score 0.30
- sum of eosinophil and basophil counts · score 0.30
- cataract · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6P1J6-F1 | alphafold | PREDICTED | 81.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6P1J6.
Amino-acid sequence (1458 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLB1?
The strongest Open Targets associations for PLB1 are eosinophil count, eosinophil percentage of leukocytes, bone density, urate measurement and triglyceride measurement.
How long is the PLB1 protein?
The Homo sapiens PLB1 protein (UniProt Q6P1J6) is 1458 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6P1J6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6P1J6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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