Parafibromin (CDC73)
Homo sapiens — UniProt Q6P1J9
Data last refreshed: (UniProt release unknown)
Key facts
Parafibromin (CDC73) is a protein from Homo sapiens identified by UniProt accession Q6P1J9, 531 residues long. MolForge cross-references it against 0 known binders and 304 disease associations.
- UniProt accession: Q6P1J9; gene symbol CDC73.
- Organism: Homo sapiens.
- Length: 531 amino acids.
- Top disease associations (Open Targets): parathyroid adenoma, hyperparathyroidism 2 with jaw tumors and Hyperparathyroidism-jaw tumor syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Parafibromin |
|---|---|
| UniProt accession | Q6P1J9 |
| Gene | CDC73 |
| Organism | Homo sapiens |
| Length | 531 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (304)
Diseases linked to this target (Open Targets).
- parathyroid adenoma · score 0.73
- hyperparathyroidism 2 with jaw tumors · score 0.71
- Hyperparathyroidism-jaw tumor syndrome · score 0.70
- hyperparathyroidism · score 0.66
- familial isolated hyperparathyroidism · score 0.64
- Parathyroid Gland Carcinoma · score 0.64
- hereditary neoplastic syndrome · score 0.55
- Inherited cancer-predisposing syndrome · score 0.55
- malignant endocrine neoplasm · score 0.46
- endocrine neoplasm · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6P1J9-F1 | alphafold | PREDICTED | 73.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6P1J9.
Amino-acid sequence (531 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CDC73?
The strongest Open Targets associations for CDC73 are parathyroid adenoma, hyperparathyroidism 2 with jaw tumors, Hyperparathyroidism-jaw tumor syndrome, hyperparathyroidism and familial isolated hyperparathyroidism.
How long is the CDC73 protein?
The Homo sapiens CDC73 protein (UniProt Q6P1J9) is 531 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6P1J9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6P1J9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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