Heme transporter HRG1 (SLC48A1)
Homo sapiens — UniProt Q6P1K1
Data last refreshed: (UniProt release unknown)
Key facts
Heme transporter HRG1 (SLC48A1) is a protein from Homo sapiens identified by UniProt accession Q6P1K1, 146 residues long. MolForge cross-references it against 0 known binders and 158 disease associations.
- UniProt accession: Q6P1K1; gene symbol SLC48A1.
- Organism: Homo sapiens.
- Length: 146 amino acids.
- Target class: Transporter.
- Top disease associations (Open Targets): Hashimoto's thyroiditis, hypothyroidism and systolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Heme transporter HRG1 |
|---|---|
| UniProt accession | Q6P1K1 |
| Gene | SLC48A1 |
| Organism | Homo sapiens |
| Length | 146 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (158)
Diseases linked to this target (Open Targets).
- Hashimoto's thyroiditis · score 0.33
- hypothyroidism · score 0.26
- systolic blood pressure · score 0.24
- reticulocyte measurement · score 0.23
- mean corpuscular volume · score 0.20
- mean corpuscular hemoglobin · score 0.20
- reticulocyte count · score 0.20
- mean reticulocyte volume · score 0.19
- platelet component distribution width · score 0.15
- Immature Reticulocyte Fraction Measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6P1K1-F1 | alphafold | PREDICTED | 86.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6P1K1.
Amino-acid sequence (146 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC48A1?
The strongest Open Targets associations for SLC48A1 are Hashimoto's thyroiditis, hypothyroidism, systolic blood pressure, reticulocyte measurement and mean corpuscular volume.
How long is the SLC48A1 protein?
The Homo sapiens SLC48A1 protein (UniProt Q6P1K1) is 146 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6P1K1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6P1K1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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