General transcription factor IIH subunit 2-like protein (GTF2H2C)
Homo sapiens — UniProt Q6P1K8
Data last refreshed: (UniProt release unknown)
Key facts
General transcription factor IIH subunit 2-like protein (GTF2H2C) is a protein from Homo sapiens identified by UniProt accession Q6P1K8, 395 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q6P1K8; gene symbol GTF2H2C.
- Organism: Homo sapiens.
- Length: 395 amino acids.
- Top disease associations (Open Targets): aspartate aminotransferase measurement, mean reticulocyte volume and total blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | General transcription factor IIH subunit 2-like protein |
|---|---|
| UniProt accession | Q6P1K8 |
| Gene | GTF2H2C |
| Organism | Homo sapiens |
| Length | 395 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- aspartate aminotransferase measurement · score 0.32
- mean reticulocyte volume · score 0.11
- total blood protein measurement · score 0.07
- serum gamma-glutamyl transferase measurement · score 0.07
- Red cell distribution width · score 0.02
- lung adenocarcinoma · score 0.01
- lung carcinoma · score 0.01
- non-small cell lung carcinoma · score 0.01
- primary ovarian insufficiency · score 0.01
- adrenal cortex carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6P1K8-F1 | alphafold | PREDICTED | 84.06 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6P1K8.
Amino-acid sequence (395 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GTF2H2C?
The strongest Open Targets associations for GTF2H2C are aspartate aminotransferase measurement, mean reticulocyte volume, total blood protein measurement, serum gamma-glutamyl transferase measurement and Red cell distribution width.
How long is the GTF2H2C protein?
The Homo sapiens GTF2H2C protein (UniProt Q6P1K8) is 395 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6P1K8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6P1K8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.