LETM1 domain-containing protein 1 (LETMD1)

About LETM1 domain-containing protein 1

LETM1 domain-containing protein 1 (LETMD1) is a protein from Homo sapiens identified by UniProt accession Q6P1Q0, 360 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	LETM1 domain-containing protein 1
UniProt accession	Q6P1Q0
Gene	LETMD1
Organism	Homo sapiens
Length	360 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (47)

Diseases linked to this target (Open Targets).

pancreatic neoplasm · score 0.07
MODY · score 0.06
cancer · score 0.05
hepatocellular carcinoma · score 0.05
neoplasm · score 0.05
Familial partial lipodystrophy, Köbberling type · score 0.04
multiple symmetric lipomatosis · score 0.04
hyperproinsulinemia · score 0.04
mean corpuscular hemoglobin concentration · score 0.04
glycogen storage disorder due to hepatic glycogen synthase deficiency · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6P1Q0-F1	alphafold	PREDICTED	81.26	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6P1Q0.

Amino-acid sequence (360 residues)

MALSRVCWAR SAVWGSAVTP GHFVTRRLQL GRSGLAWGAP RSSKLHLSPK ADVKNLMSYV VTKTKAINGK YHRFLGRHFP RFYVLYTIFM KGLQMLWADA KKARRIKTNM WKHNIKFHQL PYREMEHLRQ FRQDVTKCLF LGIISIPPFA NYLVFLLMYL FPRQLLIRHF WTPKQQTDFL DIYHAFRKQS HPEIISYLEK VIPLISDAGL RWRLTDLCTK IQRGTHPAIH DILALRECFS NHPLGMNQLQ ALHVKALSRA MLLTSYLPPP LLRHRLKTHT TVIHQLDKAL AKLGIGQLTA QEVKSACYLR GLNSTHIGED RCRTWLGEWL QISCSLKEAE LSLLLHNVVL LSTNYLGTRR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards