tRNA N(3)-cytidine methyltransferase METTL2B (METTL2B)
Homo sapiens — UniProt Q6P1Q9
Data last refreshed: (UniProt release unknown)
Key facts
tRNA N(3)-cytidine methyltransferase METTL2B (METTL2B) is a protein from Homo sapiens identified by UniProt accession Q6P1Q9, 378 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.
- UniProt accession: Q6P1Q9; gene symbol METTL2B.
- Organism: Homo sapiens.
- Length: 378 amino acids.
- Top disease associations (Open Targets): monocyte count, monocyte percentage of leukocytes and cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA N(3)-cytidine methyltransferase METTL2B |
|---|---|
| UniProt accession | Q6P1Q9 |
| Gene | METTL2B |
| Organism | Homo sapiens |
| Length | 378 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (14)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.29
- monocyte percentage of leukocytes · score 0.03
- cancer · score 0.02
- infection · score 0.01
- infect · score 0.01
- neoplasm · score 0.01
- cutaneous melanoma · score 0.00
- glioblastoma multiforme · score 0.00
- ovarian serous cystadenocarcinoma · score 0.00
- uterine corpus endometrial carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6P1Q9-F1 | alphafold | PREDICTED | 81.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6P1Q9.
Amino-acid sequence (378 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with METTL2B?
The strongest Open Targets associations for METTL2B are monocyte count, monocyte percentage of leukocytes, cancer, infection and infect.
How long is the METTL2B protein?
The Homo sapiens METTL2B protein (UniProt Q6P1Q9) is 378 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6P1Q9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6P1Q9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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