tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like (DUS1L)
Homo sapiens — UniProt Q6P1R4
Data last refreshed: (UniProt release unknown)
Key facts
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like (DUS1L) is a protein from Homo sapiens identified by UniProt accession Q6P1R4, 473 residues long. MolForge cross-references it against 0 known binders and 9 disease associations.
- UniProt accession: Q6P1R4; gene symbol DUS1L.
- Organism: Homo sapiens.
- Length: 473 amino acids.
- Top disease associations (Open Targets): FEV/FVC ratio, triple-negative breast cancer and chronic kidney disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like |
|---|---|
| UniProt accession | Q6P1R4 |
| Gene | DUS1L |
| Organism | Homo sapiens |
| Length | 473 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (9)
Diseases linked to this target (Open Targets).
- FEV/FVC ratio · score 0.02
- triple-negative breast cancer · score 0.01
- chronic kidney disease · score 0.00
- glioblastoma multiforme · score 0.00
- cancer · score 0.00
- colorectal adenocarcinoma · score 0.00
- neoplasm · score 0.00
- pachyonychia congenita · score 0.00
- COVID-19 · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6P1R4-F1 | alphafold | PREDICTED | 87.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6P1R4.
Amino-acid sequence (473 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DUS1L?
The strongest Open Targets associations for DUS1L are FEV/FVC ratio, triple-negative breast cancer, chronic kidney disease, glioblastoma multiforme and cancer.
How long is the DUS1L protein?
The Homo sapiens DUS1L protein (UniProt Q6P1R4) is 473 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6P1R4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6P1R4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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