DENN domain-containing protein 1B (DENND1B)

About DENN domain-containing protein 1B

DENN domain-containing protein 1B (DENND1B) is a protein from Homo sapiens identified by UniProt accession Q6P3S1, 775 residues long. MolForge cross-references it against 0 known binders and 129 disease associations.

Target properties

Protein name	DENN domain-containing protein 1B
UniProt accession	Q6P3S1
Gene	DENND1B
Organism	Homo sapiens
Length	775 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (129)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.39
inflammatory bowel disease · score 0.37
neurodegenerative disease · score 0.36
Crohn's disease · score 0.35
neuroticism measurement · score 0.35
psoriasis · score 0.34
lymphocyte percentage of leukocytes · score 0.34
primary biliary cirrhosis · score 0.34
unipolar depression · score 0.31
self reported educational attainment · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6P3S1-F1	alphafold	PREDICTED	66.71	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6P3S1.

Amino-acid sequence (775 residues)

MDCRTKANPD RTFDLVLKVK CHASENEDPV VLWKFPEDFG DQEILQSVPK FCFPFDVERV SQNQVGQHFT FVLTDIESKQ RFGFCRLTSG GTICLCILSY LPWFEVYYKL LNTLADYLAK ELENDLNETL RSLYNHPVPK ANTPVNLSVN QEIFIACEQV LKDQPALVPH SYFIAPDVTG LPTIPESRNL TEYFVAVDVN NMLQLYASML HERRIVIISS KLSTLTACIH GSAALLYPMY WQHIYIPVLP PHLLDYCCAP MPYLIGIHSS LIERVKNKSL EDVVMLNVDT NTLESPFSDL NNLPSDVVSA LKNKLKKQST ATGDGVARAF LRAQAALFGS YRDALRYKPG EPITFCEESF VKHRSSVMKQ FLETAINLQL FKQFIDGRLA KLNAGRGFSD VFEEEITSGG FCGGNPRSYQ QWVHTVKKGG ALFNTAMTKA TPAVRTAYKF AKNHAKLGLK EVKSKLKHKE NEEDYGTCSS SVQYTPVYKL HNEKGGNSEK RKLAQARLKR PLKSLDGALY DDEDDDDIER ASKLSSEDGE EASAYLYESD DSVETRVKTP YSGEMDLLGE ILDTLSTHSS DQGKLAAAKS LDFFRSMDDI DYKPTNKSNA PSENNLAFLC GGSGDQAEWN LGQDDSALHG KHLPPSPRKR VSSSGLTDSL FILKEENSNK HLGADNVSDP TSGLDFQLTS PEVSQTDKGK TEKRETLSQI SDDLLIPGLG RHSSTFVPWE KEGKEAKETS EDIGLLHEVV SLCHMTSDFQ QSLNISDKNT NGNQT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards