F-box only protein 42 (FBXO42)
Homo sapiens — UniProt Q6P3S6
Data last refreshed: (UniProt release unknown)
Key facts
F-box only protein 42 (FBXO42) is a protein from Homo sapiens identified by UniProt accession Q6P3S6, 717 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.
- UniProt accession: Q6P3S6; gene symbol FBXO42.
- Organism: Homo sapiens.
- Length: 717 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lysosomal storage disease and brain measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | F-box only protein 42 |
|---|---|
| UniProt accession | Q6P3S6 |
| Gene | FBXO42 |
| Organism | Homo sapiens |
| Length | 717 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (58)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- lysosomal storage disease · score 0.36
- brain measurement · score 0.13
- cortical surface area measurement · score 0.13
- cortical thickness · score 0.13
- creatinine measurement · score 0.11
- mean corpuscular hemoglobin concentration · score 0.10
- glomerular filtration rate · score 0.08
- body fat percentage · score 0.08
- breast cancer · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6P3S6-F1 | alphafold | PREDICTED | 63.22 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6P3S6.
Amino-acid sequence (717 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FBXO42?
The strongest Open Targets associations for FBXO42 are neurodegenerative disease, lysosomal storage disease, brain measurement, cortical surface area measurement and cortical thickness.
How long is the FBXO42 protein?
The Homo sapiens FBXO42 protein (UniProt Q6P3S6) is 717 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6P3S6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6P3S6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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