Tetratricopeptide repeat protein 27 (TTC27)
Homo sapiens — UniProt Q6P3X3
Data last refreshed: (UniProt release unknown)
Key facts
Tetratricopeptide repeat protein 27 (TTC27) is a protein from Homo sapiens identified by UniProt accession Q6P3X3, 843 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.
- UniProt accession: Q6P3X3; gene symbol TTC27.
- Organism: Homo sapiens.
- Length: 843 amino acids.
- Top disease associations (Open Targets): bilirubin measurement, blood protein measurement and IGF-1 measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tetratricopeptide repeat protein 27 |
|---|---|
| UniProt accession | Q6P3X3 |
| Gene | TTC27 |
| Organism | Homo sapiens |
| Length | 843 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (54)
Diseases linked to this target (Open Targets).
- bilirubin measurement · score 0.37
- blood protein measurement · score 0.32
- IGF-1 measurement · score 0.27
- allergic rhinitis · score 0.25
- seborrheic keratosis · score 0.24
- facial pigmentation measurement · score 0.20
- sex hormone-binding globulin measurement · score 0.19
- Red cell distribution width · score 0.19
- mathematical ability · score 0.18
- smoking status measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6P3X3-F1 | alphafold | PREDICTED | 90.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6P3X3.
Amino-acid sequence (843 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TTC27?
The strongest Open Targets associations for TTC27 are bilirubin measurement, blood protein measurement, IGF-1 measurement, allergic rhinitis and seborrheic keratosis.
How long is the TTC27 protein?
The Homo sapiens TTC27 protein (UniProt Q6P3X3) is 843 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6P3X3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6P3X3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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