Sideroflexin-4 (SFXN4)
Homo sapiens — UniProt Q6P4A7
Data last refreshed: (UniProt release unknown)
Key facts
Sideroflexin-4 (SFXN4) is a protein from Homo sapiens identified by UniProt accession Q6P4A7, 337 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.
- UniProt accession: Q6P4A7; gene symbol SFXN4.
- Organism: Homo sapiens.
- Length: 337 amino acids.
- Top disease associations (Open Targets): growth and developmental delay-hypotonia-vision impairment-lactic acidosis syndrome, combined oxidative phosphorylation defect type 15 and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sideroflexin-4 |
|---|---|
| UniProt accession | Q6P4A7 |
| Gene | SFXN4 |
| Organism | Homo sapiens |
| Length | 337 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (40)
Diseases linked to this target (Open Targets).
- growth and developmental delay-hypotonia-vision impairment-lactic acidosis syndrome · score 0.74
- combined oxidative phosphorylation defect type 15 · score 0.53
- neurodegenerative disease · score 0.53
- genetic disorder · score 0.41
- mitochondrial disease · score 0.37
- BMI-adjusted waist circumference · score 0.18
- neurofibrillary tangles measurement · score 0.16
- calcium measurement · score 0.10
- neutrophil count · score 0.09
- carpal tunnel syndrome · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6P4A7-F1 | alphafold | PREDICTED | 85.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6P4A7.
Amino-acid sequence (337 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SFXN4?
The strongest Open Targets associations for SFXN4 are growth and developmental delay-hypotonia-vision impairment-lactic acidosis syndrome, combined oxidative phosphorylation defect type 15, neurodegenerative disease, genetic disorder and mitochondrial disease.
How long is the SFXN4 protein?
The Homo sapiens SFXN4 protein (UniProt Q6P4A7) is 337 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6P4A7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6P4A7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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