Lysosomal leucine aminopeptidase (PLBD1)
Homo sapiens — UniProt Q6P4A8
Data last refreshed: (UniProt release unknown)
Key facts
Lysosomal leucine aminopeptidase (PLBD1) is a protein from Homo sapiens identified by UniProt accession Q6P4A8, 553 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.
- UniProt accession: Q6P4A8; gene symbol PLBD1.
- Organism: Homo sapiens.
- Length: 553 amino acids.
- Top disease associations (Open Targets): monocyte percentage of leukocytes, eosinophil count and glioblastoma multiforme.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Lysosomal leucine aminopeptidase |
|---|---|
| UniProt accession | Q6P4A8 |
| Gene | PLBD1 |
| Organism | Homo sapiens |
| Length | 553 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (69)
Diseases linked to this target (Open Targets).
- monocyte percentage of leukocytes · score 0.27
- eosinophil count · score 0.23
- glioblastoma multiforme · score 0.20
- breast adenocarcinoma · score 0.18
- cutaneous melanoma · score 0.14
- alkaline phosphatase measurement · score 0.10
- urate measurement · score 0.09
- mean corpuscular volume · score 0.08
- cognitive function measurement · score 0.08
- cancer · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6P4A8-F1 | alphafold | PREDICTED | 91.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6P4A8.
Amino-acid sequence (553 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLBD1?
The strongest Open Targets associations for PLBD1 are monocyte percentage of leukocytes, eosinophil count, glioblastoma multiforme, breast adenocarcinoma and cutaneous melanoma.
How long is the PLBD1 protein?
The Homo sapiens PLBD1 protein (UniProt Q6P4A8) is 553 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6P4A8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6P4A8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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