Integrator complex assembly factor WDR73 (WDR73)

About Integrator complex assembly factor WDR73

Integrator complex assembly factor WDR73 (WDR73) is a protein from Homo sapiens identified by UniProt accession Q6P4I2, 378 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.

Target properties

Protein name	Integrator complex assembly factor WDR73
UniProt accession	Q6P4I2
Gene	WDR73
Organism	Homo sapiens
Length	378 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (69)

Diseases linked to this target (Open Targets).

Galloway-Mowat syndrome · score 0.76
CAMOS syndrome · score 0.76
neurodegenerative disease · score 0.46
genetic disorder · score 0.45
nephrotic syndrome · score 0.36
Dystonia · score 0.33
dystonic disorder · score 0.33
Seizure · score 0.33
Abnormality of the nervous system · score 0.27
eosinophil count · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6P4I2-F1	alphafold	PREDICTED	87.43	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6P4I2.

Amino-acid sequence (378 residues)

MDPGDDWLVE SLRLYQDFYA FDLSGATRVL EWIDDKGVFV AGYESLKKNE ILHLKLPLRL SVKENKGLFP ERDFKVRHGG FSDRSIFDLK HVPHTRLLVT SGLPGCYLQV WQVAEDSDVI KAVSTIAVHE KEESLWPRVA VFSTLAPGVL HGARLRSLQV VDLESRKTTY TSDVSDSEEL SSLQVLDADT FAFCCASGRL GLVDTRQKWA PLENRSPGPG SGGERWCAEV GSWGQGPGPS IASLGSDGRL CLLDPRDLCH PVSSVQCPVS VPSPDPELLR VTWAPGLKNC LAISGFDGTV QVYDATSWDG TRSQDGTRSQ VEPLFTHRGH IFLDGNGMDP APLVTTHTWH PCRPRTLLSA TNDASLHVWD WVDLCAPR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards