Nuclear factor related to kappa-B-binding protein (NFRKB)
Homo sapiens — UniProt Q6P4R8
Data last refreshed: (UniProt release unknown)
Key facts
Nuclear factor related to kappa-B-binding protein (NFRKB) is a protein from Homo sapiens identified by UniProt accession Q6P4R8, 1299 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: Q6P4R8; gene symbol NFRKB.
- Organism: Homo sapiens.
- Length: 1299 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Red cell distribution width and reticulocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nuclear factor related to kappa-B-binding protein |
|---|---|
| UniProt accession | Q6P4R8 |
| Gene | NFRKB |
| Organism | Homo sapiens |
| Length | 1299 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- Red cell distribution width · score 0.30
- reticulocyte count · score 0.28
- reticulocyte measurement · score 0.25
- pancreatic adenocarcinoma · score 0.24
- low grade glioma · score 0.23
- breast adenocarcinoma · score 0.23
- glioblastoma multiforme · score 0.18
- ovarian cancer · score 0.18
- clear cell renal carcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6P4R8-F1 | alphafold | PREDICTED | 54.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6P4R8.
Amino-acid sequence (1299 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NFRKB?
The strongest Open Targets associations for NFRKB are neurodegenerative disease, Red cell distribution width, reticulocyte count, reticulocyte measurement and pancreatic adenocarcinoma.
How long is the NFRKB protein?
The Homo sapiens NFRKB protein (UniProt Q6P4R8) is 1299 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6P4R8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6P4R8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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