Protein LEG1 homolog (LEG1)
Homo sapiens — UniProt Q6P5S2
Data last refreshed: (UniProt release unknown)
Key facts
Protein LEG1 homolog (LEG1) is a protein from Homo sapiens identified by UniProt accession Q6P5S2, 330 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.
- UniProt accession: Q6P5S2; gene symbol LEG1.
- Organism: Homo sapiens.
- Length: 330 amino acids.
- Top disease associations (Open Targets): body height, hepcidin:ferritin ratio and Barrett's esophagus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein LEG1 homolog |
|---|---|
| UniProt accession | Q6P5S2 |
| Gene | LEG1 |
| Organism | Homo sapiens |
| Length | 330 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (21)
Diseases linked to this target (Open Targets).
- body height · score 0.33
- hepcidin:ferritin ratio · score 0.08
- Barrett's esophagus · score 0.06
- body fat percentage · score 0.04
- gastric carcinoma · score 0.04
- body mass index · score 0.04
- self reported educational attainment · score 0.04
- mathematical ability · score 0.02
- heel bone mineral density · score 0.02
- non-small cell lung carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6P5S2-F1 | alphafold | PREDICTED | 87.70 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6P5S2.
Amino-acid sequence (330 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LEG1?
The strongest Open Targets associations for LEG1 are body height, hepcidin:ferritin ratio, Barrett's esophagus, body fat percentage and gastric carcinoma.
How long is the LEG1 protein?
The Homo sapiens LEG1 protein (UniProt Q6P5S2) is 330 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6P5S2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6P5S2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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