Zinc transporter ZIP4 (SLC39A4)
Homo sapiens — UniProt Q6P5W5
Data last refreshed: (UniProt release unknown)
Key facts
Zinc transporter ZIP4 (SLC39A4) is a protein from Homo sapiens identified by UniProt accession Q6P5W5, 647 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.
- UniProt accession: Q6P5W5; gene symbol SLC39A4.
- Organism: Homo sapiens.
- Length: 647 amino acids.
- Target class: Transporter.
- Top disease associations (Open Targets): acrodermatitis enteropathica, genetic disorder and alkaline phosphatase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc transporter ZIP4 |
|---|---|
| UniProt accession | Q6P5W5 |
| Gene | SLC39A4 |
| Organism | Homo sapiens |
| Length | 647 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (108)
Diseases linked to this target (Open Targets).
- acrodermatitis enteropathica · score 0.83
- genetic disorder · score 0.47
- alkaline phosphatase measurement · score 0.32
- sex hormone-binding globulin measurement · score 0.28
- mean corpuscular volume · score 0.18
- mean reticulocyte volume · score 0.12
- neoplasm · score 0.10
- hepatocellular carcinoma · score 0.08
- MODY · score 0.07
- esophageal squamous cell carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6P5W5-F1 | alphafold | PREDICTED | 74.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6P5W5.
Amino-acid sequence (647 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC39A4?
The strongest Open Targets associations for SLC39A4 are acrodermatitis enteropathica, genetic disorder, alkaline phosphatase measurement, sex hormone-binding globulin measurement and mean corpuscular volume.
How long is the SLC39A4 protein?
The Homo sapiens SLC39A4 protein (UniProt Q6P5W5) is 647 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6P5W5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6P5W5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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