Synaptic plasticity regulator PANTS (C22orf39)
Homo sapiens — UniProt Q6P5X5
Data last refreshed: (UniProt release unknown)
Key facts
Synaptic plasticity regulator PANTS (C22orf39) is a protein from Homo sapiens identified by UniProt accession Q6P5X5, 105 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.
- UniProt accession: Q6P5X5; gene symbol C22orf39.
- Organism: Homo sapiens.
- Length: 105 amino acids.
- Top disease associations (Open Targets): isolated congenital hypogonadotropic hypogonadism, Testicular regression syndrome and 46,XY complete gonadal dysgenesis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Synaptic plasticity regulator PANTS |
|---|---|
| UniProt accession | Q6P5X5 |
| Gene | C22orf39 |
| Organism | Homo sapiens |
| Length | 105 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (38)
Diseases linked to this target (Open Targets).
- isolated congenital hypogonadotropic hypogonadism · score 0.06
- Testicular regression syndrome · score 0.06
- 46,XY complete gonadal dysgenesis · score 0.06
- 46,XX testicular disorder of sex development · score 0.06
- azoospermia · score 0.06
- 46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency · score 0.06
- benign prostatic hyperplasia · score 0.06
- total blood protein measurement · score 0.05
- cryptorchidism · score 0.05
- familial male-limited precocious puberty · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6P5X5-F1 | alphafold | PREDICTED | 89.47 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6P5X5.
Amino-acid sequence (105 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with C22orf39?
The strongest Open Targets associations for C22orf39 are isolated congenital hypogonadotropic hypogonadism, Testicular regression syndrome, 46,XY complete gonadal dysgenesis, 46,XX testicular disorder of sex development and azoospermia.
How long is the C22orf39 protein?
The Homo sapiens C22orf39 protein (UniProt Q6P5X5) is 105 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6P5X5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6P5X5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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