Connector enhancer of kinase suppressor of ras 3 (CNKSR3)
Homo sapiens — UniProt Q6P9H4
Data last refreshed: (UniProt release unknown)
Key facts
Connector enhancer of kinase suppressor of ras 3 (CNKSR3) is a protein from Homo sapiens identified by UniProt accession Q6P9H4, 555 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: Q6P9H4; gene symbol CNKSR3.
- Organism: Homo sapiens.
- Length: 555 amino acids.
- Top disease associations (Open Targets): serum gamma-glutamyl transferase measurement, cystatin C measurement and creatinine measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Connector enhancer of kinase suppressor of ras 3 |
|---|---|
| UniProt accession | Q6P9H4 |
| Gene | CNKSR3 |
| Organism | Homo sapiens |
| Length | 555 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- serum gamma-glutamyl transferase measurement · score 0.40
- cystatin C measurement · score 0.31
- creatinine measurement · score 0.31
- glomerular filtration rate · score 0.30
- diabetic nephropathy · score 0.29
- lipoprotein A measurement · score 0.29
- peak expiratory flow · score 0.28
- neurodegenerative disease · score 0.24
- serum urea measurement · score 0.05
- blood urea nitrogen measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6P9H4-F1 | alphafold | PREDICTED | 64.47 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6P9H4.
Amino-acid sequence (555 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CNKSR3?
The strongest Open Targets associations for CNKSR3 are serum gamma-glutamyl transferase measurement, cystatin C measurement, creatinine measurement, glomerular filtration rate and diabetic nephropathy.
How long is the CNKSR3 protein?
The Homo sapiens CNKSR3 protein (UniProt Q6P9H4) is 555 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6P9H4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6P9H4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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