Gap junction beta-7 protein (GJB7)
Homo sapiens — UniProt Q6PEY0
Data last refreshed: (UniProt release unknown)
Key facts
Gap junction beta-7 protein (GJB7) is a protein from Homo sapiens identified by UniProt accession Q6PEY0, 223 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q6PEY0; gene symbol GJB7.
- Organism: Homo sapiens.
- Length: 223 amino acids.
- Top disease associations (Open Targets): eosinophil count, neurodegenerative disease and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Gap junction beta-7 protein |
|---|---|
| UniProt accession | Q6PEY0 |
| Gene | GJB7 |
| Organism | Homo sapiens |
| Length | 223 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.35
- neurodegenerative disease · score 0.31
- mean corpuscular volume · score 0.30
- IGF-1 measurement · score 0.26
- mean corpuscular hemoglobin concentration · score 0.24
- lymphocyte percentage of leukocytes · score 0.22
- neutrophil percentage of leukocytes · score 0.17
- neutrophil count · score 0.15
- eosinophil percentage of leukocytes · score 0.15
- myeloid white cell count · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6PEY0-F1 | alphafold | PREDICTED | 83.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6PEY0.
Amino-acid sequence (223 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GJB7?
The strongest Open Targets associations for GJB7 are eosinophil count, neurodegenerative disease, mean corpuscular volume, IGF-1 measurement and mean corpuscular hemoglobin concentration.
How long is the GJB7 protein?
The Homo sapiens GJB7 protein (UniProt Q6PEY0) is 223 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6PEY0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6PEY0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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