Serine/threonine-protein kinase ULK3 (ULK3)
Homo sapiens — UniProt Q6PHR2
Data last refreshed: (UniProt release unknown)
Key facts
Serine/threonine-protein kinase ULK3 (ULK3) is a protein from Homo sapiens identified by UniProt accession Q6PHR2, 472 residues long. MolForge cross-references it against 17 known binders and 86 disease associations.
- UniProt accession: Q6PHR2; gene symbol ULK3.
- Organism: Homo sapiens.
- Length: 472 amino acids.
- Top disease associations (Open Targets): Alzheimer disease, multiple sclerosis and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/threonine-protein kinase ULK3 |
|---|---|
| UniProt accession | Q6PHR2 |
| Gene | ULK3 |
| Organism | Homo sapiens |
| Length | 472 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (86)
Diseases linked to this target (Open Targets).
- Alzheimer disease · score 0.29
- multiple sclerosis · score 0.29
- neurodegenerative disease · score 0.29
- Parkinson disease · score 0.29
- lysosomal storage disease · score 0.29
- lymphocyte count · score 0.23
- neutrophil percentage of leukocytes · score 0.22
- monocyte count · score 0.20
- cystatin C measurement · score 0.17
- lymphocyte percentage of leukocytes · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6PHR2-F1 | alphafold | PREDICTED | 88.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6PHR2.
Amino-acid sequence (472 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ULK3?
The strongest Open Targets associations for ULK3 are Alzheimer disease, multiple sclerosis, neurodegenerative disease, Parkinson disease and lysosomal storage disease.
How long is the ULK3 protein?
The Homo sapiens ULK3 protein (UniProt Q6PHR2) is 472 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6PHR2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6PHR2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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