Iodotyrosine deiodinase 1 (IYD)
Homo sapiens — UniProt Q6PHW0
Data last refreshed: (UniProt release unknown)
Key facts
Iodotyrosine deiodinase 1 (IYD) is a protein from Homo sapiens identified by UniProt accession Q6PHW0, 289 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: Q6PHW0; gene symbol IYD.
- Organism: Homo sapiens.
- Length: 289 amino acids.
- Top disease associations (Open Targets): familial thyroid dyshormonogenesis, pulmonary embolism and congenital hypothyroidism.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Iodotyrosine deiodinase 1 |
|---|---|
| UniProt accession | Q6PHW0 |
| Gene | IYD |
| Organism | Homo sapiens |
| Length | 289 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- familial thyroid dyshormonogenesis · score 0.57
- pulmonary embolism · score 0.26
- congenital hypothyroidism · score 0.18
- cutaneous melanoma · score 0.16
- Barrett's esophagus · score 0.07
- esophageal adenocarcinoma · score 0.04
- clear cell renal carcinoma · score 0.04
- hepatocellular carcinoma · score 0.03
- hypothyroidism · score 0.02
- psoriasis · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6PHW0-F1 | alphafold | PREDICTED | 88.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6PHW0.
Amino-acid sequence (289 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IYD?
The strongest Open Targets associations for IYD are familial thyroid dyshormonogenesis, pulmonary embolism, congenital hypothyroidism, cutaneous melanoma and Barrett's esophagus.
How long is the IYD protein?
The Homo sapiens IYD protein (UniProt Q6PHW0) is 289 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6PHW0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6PHW0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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