SPRY domain-containing SOCS box protein 3 (SPSB3)
Homo sapiens — UniProt Q6PJ21
Data last refreshed: (UniProt release unknown)
Key facts
SPRY domain-containing SOCS box protein 3 (SPSB3) is a protein from Homo sapiens identified by UniProt accession Q6PJ21, 355 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.
- UniProt accession: Q6PJ21; gene symbol SPSB3.
- Organism: Homo sapiens.
- Length: 355 amino acids.
- Top disease associations (Open Targets): lean body mass, sitting height measurement and anthropometric measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SPRY domain-containing SOCS box protein 3 |
|---|---|
| UniProt accession | Q6PJ21 |
| Gene | SPSB3 |
| Organism | Homo sapiens |
| Length | 355 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (40)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.62
- sitting height measurement · score 0.56
- anthropometric measurement · score 0.50
- Reduced insulin like growth factor binding protein acid labile subunit concentration · score 0.50
- short stature due to primary acid-labile subunit deficiency · score 0.50
- body height · score 0.44
- whole body water mass · score 0.43
- appendicular lean mass · score 0.35
- base metabolic rate measurement · score 0.33
- body weights and measures · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6PJ21-F1 | alphafold | PREDICTED | 76.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6PJ21.
Amino-acid sequence (355 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPSB3?
The strongest Open Targets associations for SPSB3 are lean body mass, sitting height measurement, anthropometric measurement, Reduced insulin like growth factor binding protein acid labile subunit concentration and short stature due to primary acid-labile subunit deficiency.
How long is the SPSB3 protein?
The Homo sapiens SPSB3 protein (UniProt Q6PJ21) is 355 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6PJ21 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6PJ21 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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