F-box only protein 46 (FBXO46)
Homo sapiens — UniProt Q6PJ61
Data last refreshed: (UniProt release unknown)
Key facts
F-box only protein 46 (FBXO46) is a protein from Homo sapiens identified by UniProt accession Q6PJ61, 603 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.
- UniProt accession: Q6PJ61; gene symbol FBXO46.
- Organism: Homo sapiens.
- Length: 603 amino acids.
- Top disease associations (Open Targets): mean corpuscular hemoglobin, brain measurement and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | F-box only protein 46 |
|---|---|
| UniProt accession | Q6PJ61 |
| Gene | FBXO46 |
| Organism | Homo sapiens |
| Length | 603 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (11)
Diseases linked to this target (Open Targets).
- mean corpuscular hemoglobin · score 0.13
- brain measurement · score 0.07
- mean corpuscular volume · score 0.07
- left atrial volume measurement · score 0.04
- mean corpuscular hemoglobin concentration · score 0.03
- body height · score 0.02
- ulcerative colitis · score 0.01
- cancer · score 0.01
- neoplasm · score 0.01
- chronic obstructive pulmonary disease · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6PJ61-F1 | alphafold | PREDICTED | 44.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6PJ61.
Amino-acid sequence (603 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FBXO46?
The strongest Open Targets associations for FBXO46 are mean corpuscular hemoglobin, brain measurement, mean corpuscular volume, left atrial volume measurement and mean corpuscular hemoglobin concentration.
How long is the FBXO46 protein?
The Homo sapiens FBXO46 protein (UniProt Q6PJ61) is 603 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6PJ61 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6PJ61 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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