Integrator complex assembly factor BRAT1 (BRAT1)
Homo sapiens — UniProt Q6PJG6
Data last refreshed: (UniProt release unknown)
Key facts
Integrator complex assembly factor BRAT1 (BRAT1) is a protein from Homo sapiens identified by UniProt accession Q6PJG6, 821 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.
- UniProt accession: Q6PJG6; gene symbol BRAT1.
- Organism: Homo sapiens.
- Length: 821 amino acids.
- Top disease associations (Open Targets): Lethal neonatal spasticity-epileptic encephalopathy syndrome, neurodevelopmental disorder with cerebellar atrophy and with or without seizures and neonatal-onset encephalopathy with rigidity and seizures.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Integrator complex assembly factor BRAT1 |
|---|---|
| UniProt accession | Q6PJG6 |
| Gene | BRAT1 |
| Organism | Homo sapiens |
| Length | 821 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (60)
Diseases linked to this target (Open Targets).
- Lethal neonatal spasticity-epileptic encephalopathy syndrome · score 0.79
- neurodevelopmental disorder with cerebellar atrophy and with or without seizures · score 0.76
- neonatal-onset encephalopathy with rigidity and seizures · score 0.75
- genetic disorder · score 0.52
- Seizure · score 0.37
- platelet component distribution width · score 0.27
- monocyte count · score 0.26
- mean corpuscular volume · score 0.26
- platelet crit · score 0.20
- monocyte percentage of leukocytes · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6PJG6-F1 | alphafold | PREDICTED | 84.80 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6PJG6.
Amino-acid sequence (821 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BRAT1?
The strongest Open Targets associations for BRAT1 are Lethal neonatal spasticity-epileptic encephalopathy syndrome, neurodevelopmental disorder with cerebellar atrophy and with or without seizures, neonatal-onset encephalopathy with rigidity and seizures, genetic disorder and Seizure.
How long is the BRAT1 protein?
The Homo sapiens BRAT1 protein (UniProt Q6PJG6) is 821 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6PJG6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6PJG6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.