Leucine-rich repeat and fibronectin type-III domain-containing protein 4 (LRFN4)
Homo sapiens — UniProt Q6PJG9
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat and fibronectin type-III domain-containing protein 4 (LRFN4) is a protein from Homo sapiens identified by UniProt accession Q6PJG9, 635 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.
- UniProt accession: Q6PJG9; gene symbol LRFN4.
- Organism: Homo sapiens.
- Length: 635 amino acids.
- Top disease associations (Open Targets): pyruvate carboxylase deficiency disease, bipolar disorder and bipolar I disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat and fibronectin type-III domain-containing protein 4 |
|---|---|
| UniProt accession | Q6PJG9 |
| Gene | LRFN4 |
| Organism | Homo sapiens |
| Length | 635 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (25)
Diseases linked to this target (Open Targets).
- pyruvate carboxylase deficiency disease · score 0.34
- bipolar disorder · score 0.14
- bipolar I disorder · score 0.13
- chronotype measurement · score 0.11
- coffee consumption · score 0.10
- diet measurement · score 0.09
- self reported educational attainment · score 0.09
- risk-taking behaviour · score 0.08
- neoplasm · score 0.08
- cortical thickness · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6PJG9-F1 | alphafold | PREDICTED | 77.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6PJG9.
Amino-acid sequence (635 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRFN4?
The strongest Open Targets associations for LRFN4 are pyruvate carboxylase deficiency disease, bipolar disorder, bipolar I disorder, chronotype measurement and coffee consumption.
How long is the LRFN4 protein?
The Homo sapiens LRFN4 protein (UniProt Q6PJG9) is 635 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6PJG9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6PJG9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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