GATOR2 complex protein WDR59 (WDR59)
Homo sapiens — UniProt Q6PJI9
Data last refreshed: (UniProt release unknown)
Key facts
GATOR2 complex protein WDR59 (WDR59) is a protein from Homo sapiens identified by UniProt accession Q6PJI9, 974 residues long. MolForge cross-references it against 0 known binders and 75 disease associations.
- UniProt accession: Q6PJI9; gene symbol WDR59.
- Organism: Homo sapiens.
- Length: 974 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, ulcerative colitis and adolescent idiopathic scoliosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GATOR2 complex protein WDR59 |
|---|---|
| UniProt accession | Q6PJI9 |
| Gene | WDR59 |
| Organism | Homo sapiens |
| Length | 974 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (75)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- ulcerative colitis · score 0.24
- adolescent idiopathic scoliosis · score 0.20
- eosinophil count · score 0.20
- Blackfan-Diamond anemia · score 0.09
- primary familial polycythemia due to EPO receptor mutation · score 0.06
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.06
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.06
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.06
- alpha-thalassemia-myelodysplastic syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6PJI9-F1 | alphafold | PREDICTED | 72.13 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6PJI9.
Amino-acid sequence (974 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with WDR59?
The strongest Open Targets associations for WDR59 are neurodegenerative disease, ulcerative colitis, adolescent idiopathic scoliosis, eosinophil count and Blackfan-Diamond anemia.
How long is the WDR59 protein?
The Homo sapiens WDR59 protein (UniProt Q6PJI9) is 974 amino acids long.
Browse: Targets: W · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6PJI9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6PJI9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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