DNA cross-link repair 1A protein (DCLRE1A)
Homo sapiens — UniProt Q6PJP8
Data last refreshed: (UniProt release unknown)
Key facts
DNA cross-link repair 1A protein (DCLRE1A) is a protein from Homo sapiens identified by UniProt accession Q6PJP8, 1040 residues long. MolForge cross-references it against 0 known binders and 79 disease associations.
- UniProt accession: Q6PJP8; gene symbol DCLRE1A.
- Organism: Homo sapiens.
- Length: 1040 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, pulse pressure measurement and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA cross-link repair 1A protein |
|---|---|
| UniProt accession | Q6PJP8 |
| Gene | DCLRE1A |
| Organism | Homo sapiens |
| Length | 1040 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (79)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- pulse pressure measurement · score 0.22
- breast adenocarcinoma · score 0.18
- systolic blood pressure · score 0.12
- hypertension · score 0.12
- leukocyte count · score 0.10
- smoking status measurement · score 0.09
- blood pressure · score 0.09
- diastolic blood pressure · score 0.08
- neutrophil count · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6PJP8-F1 | alphafold | PREDICTED | 57.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6PJP8.
Amino-acid sequence (1040 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DCLRE1A?
The strongest Open Targets associations for DCLRE1A are neurodegenerative disease, pulse pressure measurement, breast adenocarcinoma, systolic blood pressure and hypertension.
How long is the DCLRE1A protein?
The Homo sapiens DCLRE1A protein (UniProt Q6PJP8) is 1040 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6PJP8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6PJP8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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