Dehydrogenase/reductase SDR family member 4-like 2 (DHRS4L2)
Homo sapiens — UniProt Q6PKH6
Data last refreshed: (UniProt release unknown)
Key facts
Dehydrogenase/reductase SDR family member 4-like 2 (DHRS4L2) is a protein from Homo sapiens identified by UniProt accession Q6PKH6, 232 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.
- UniProt accession: Q6PKH6; gene symbol DHRS4L2.
- Organism: Homo sapiens.
- Length: 232 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, immune deficiency, familial variable and hyper-IgM syndrome type 3.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dehydrogenase/reductase SDR family member 4-like 2 |
|---|---|
| UniProt accession | Q6PKH6 |
| Gene | DHRS4L2 |
| Organism | Homo sapiens |
| Length | 232 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (13)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- immune deficiency, familial variable · score 0.04
- hyper-IgM syndrome type 3 · score 0.04
- hyper-IgM syndrome type 2 · score 0.03
- immunodeficiency, common variable, 14 · score 0.03
- hyper-IgM syndrome type 5 · score 0.03
- neoplasm · score 0.01
- prostate adenocarcinoma · score 0.00
- glioblastoma multiforme · score 0.00
- neuroblastoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6PKH6-F1 | alphafold | PREDICTED | 85.94 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6PKH6.
Amino-acid sequence (232 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DHRS4L2?
The strongest Open Targets associations for DHRS4L2 are neurodegenerative disease, immune deficiency, familial variable, hyper-IgM syndrome type 3, hyper-IgM syndrome type 2 and immunodeficiency, common variable, 14.
How long is the DHRS4L2 protein?
The Homo sapiens DHRS4L2 protein (UniProt Q6PKH6) is 232 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6PKH6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6PKH6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.