XK-related protein 2 (XKRX)
Homo sapiens — UniProt Q6PP77
Data last refreshed: (UniProt release unknown)
Key facts
XK-related protein 2 (XKRX) is a protein from Homo sapiens identified by UniProt accession Q6PP77, 449 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.
- UniProt accession: Q6PP77; gene symbol XKRX.
- Organism: Homo sapiens.
- Length: 449 amino acids.
- Top disease associations (Open Targets): C1 inhibitor deficiency, autoimmune disease and Hashimoto's thyroiditis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | XK-related protein 2 |
|---|---|
| UniProt accession | Q6PP77 |
| Gene | XKRX |
| Organism | Homo sapiens |
| Length | 449 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (18)
Diseases linked to this target (Open Targets).
- C1 inhibitor deficiency · score 0.06
- autoimmune disease · score 0.06
- Hashimoto's thyroiditis · score 0.05
- pemphigus vulgaris · score 0.05
- autosomal systemic lupus erythematosus type 16 · score 0.04
- pancreatic adenocarcinoma · score 0.04
- Immunodeficiency due to a complement cascade protein anomaly · score 0.04
- C1Q deficiency 1 · score 0.04
- colorectal adenocarcinoma · score 0.02
- carcinoma of liver and intrahepatic biliary tract · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6PP77-F1 | alphafold | PREDICTED | 80.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6PP77.
Amino-acid sequence (449 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with XKRX?
The strongest Open Targets associations for XKRX are C1 inhibitor deficiency, autoimmune disease, Hashimoto's thyroiditis, pemphigus vulgaris and autosomal systemic lupus erythematosus type 16.
How long is the XKRX protein?
The Homo sapiens XKRX protein (UniProt Q6PP77) is 449 amino acids long.
Browse: Targets: X · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6PP77 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6PP77 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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