Complexin-2 (CPLX2)
Homo sapiens — UniProt Q6PUV4
Data last refreshed: (UniProt release unknown)
Key facts
Complexin-2 (CPLX2) is a protein from Homo sapiens identified by UniProt accession Q6PUV4, 134 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.
- UniProt accession: Q6PUV4; gene symbol CPLX2.
- Organism: Homo sapiens.
- Length: 134 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, chronotype measurement and hepatocellular carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Complexin-2 |
|---|---|
| UniProt accession | Q6PUV4 |
| Gene | CPLX2 |
| Organism | Homo sapiens |
| Length | 134 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (62)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- chronotype measurement · score 0.13
- hepatocellular carcinoma · score 0.07
- schizophrenia · score 0.06
- spinocerebellar ataxia type 14 · score 0.05
- Huntington disease · score 0.04
- astrocytoma · score 0.04
- central nervous system cancer · score 0.04
- juvenile Huntington disease · score 0.04
- atypical teratoid rhabdoid tumor · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6PUV4-F1 | alphafold | PREDICTED | 70.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6PUV4.
Amino-acid sequence (134 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CPLX2?
The strongest Open Targets associations for CPLX2 are neurodegenerative disease, chronotype measurement, hepatocellular carcinoma, schizophrenia and spinocerebellar ataxia type 14.
How long is the CPLX2 protein?
The Homo sapiens CPLX2 protein (UniProt Q6PUV4) is 134 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6PUV4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6PUV4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.