E3 ubiquitin-protein ligase TRAF7 (TRAF7)
Homo sapiens — UniProt Q6Q0C0
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase TRAF7 (TRAF7) is a protein from Homo sapiens identified by UniProt accession Q6Q0C0, 670 residues long. MolForge cross-references it against 0 known binders and 283 disease associations.
- UniProt accession: Q6Q0C0; gene symbol TRAF7.
- Organism: Homo sapiens.
- Length: 670 amino acids.
- Top disease associations (Open Targets): cardiac, facial, and digital anomalies with developmental delay, TRAF7-associated heart defect-digital anomalies-facial dysmorphism-motor and speech delay syndrome and Global developmental delay.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase TRAF7 |
|---|---|
| UniProt accession | Q6Q0C0 |
| Gene | TRAF7 |
| Organism | Homo sapiens |
| Length | 670 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (283)
Diseases linked to this target (Open Targets).
- cardiac, facial, and digital anomalies with developmental delay · score 0.74
- TRAF7-associated heart defect-digital anomalies-facial dysmorphism-motor and speech delay syndrome · score 0.50
- Global developmental delay · score 0.45
- Abnormal digit morphology · score 0.42
- Abnormality of limbs · score 0.42
- Abnormal heart morphology · score 0.42
- genetic disorder · score 0.41
- craniosynostosis · score 0.37
- Peritoneal Mesothelioma · score 0.37
- Chordoid Meningioma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6Q0C0-F1 | alphafold | PREDICTED | 79.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6Q0C0.
Amino-acid sequence (670 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRAF7?
The strongest Open Targets associations for TRAF7 are cardiac, facial, and digital anomalies with developmental delay, TRAF7-associated heart defect-digital anomalies-facial dysmorphism-motor and speech delay syndrome, Global developmental delay, Abnormal digit morphology and Abnormality of limbs.
How long is the TRAF7 protein?
The Homo sapiens TRAF7 protein (UniProt Q6Q0C0) is 670 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6Q0C0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6Q0C0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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