Apolipoprotein A-V (APOA5)
Homo sapiens — UniProt Q6Q788
Data last refreshed: (UniProt release unknown)
Key facts
Apolipoprotein A-V (APOA5) is a protein from Homo sapiens identified by UniProt accession Q6Q788, 366 residues long. MolForge cross-references it against 0 known binders and 366 disease associations.
- UniProt accession: Q6Q788; gene symbol APOA5.
- Organism: Homo sapiens.
- Length: 366 amino acids.
- Top disease associations (Open Targets): hyperlipoproteinemia type V, triglyceride measurement and high density lipoprotein cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Apolipoprotein A-V |
|---|---|
| UniProt accession | Q6Q788 |
| Gene | APOA5 |
| Organism | Homo sapiens |
| Length | 366 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (366)
Diseases linked to this target (Open Targets).
- hyperlipoproteinemia type V · score 0.77
- triglyceride measurement · score 0.69
- high density lipoprotein cholesterol measurement · score 0.69
- Hyperlipoproteinemia type 4 · score 0.65
- Hyperlipoproteinemia type 5 · score 0.64
- platelet component distribution width · score 0.61
- triglycerides:total lipids ratio · score 0.56
- total lipids in large VLDL · score 0.56
- free cholesterol to total lipids in medium LDL percentage · score 0.55
- triglycerides to total lipids in medium HDL percentage · score 0.55
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6Q788-F1 | alphafold | PREDICTED | 71.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6Q788.
Amino-acid sequence (366 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with APOA5?
The strongest Open Targets associations for APOA5 are hyperlipoproteinemia type V, triglyceride measurement, high density lipoprotein cholesterol measurement, Hyperlipoproteinemia type 4 and Hyperlipoproteinemia type 5.
How long is the APOA5 protein?
The Homo sapiens APOA5 protein (UniProt Q6Q788) is 366 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6Q788 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6Q788 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.